A man named Callum Lynch is sentenced to death by lethal injection in Texas. However, the Abstergo Company fakes his death and Callum is brought to the headquarter in Madrid, Spain. Callum meets the CEO Alan Rikkin and learns that he is a descendant of members from the Assassin's Creed, a brotherhood that protects the Apple from the Templars. The Apple is a device that contains the genetic code for free will and the Templars may dominate the humans if they find where The Apple is hidden. Callum is submitted to the Animus, a machine developed by Rikkin's daughter Sofia to relive genetic memories and find where the Apple is. Along the experiment with the Animus, Callum meets his mother and other Assassin's Creed and embraces their cause. But Rikkin, who is a Templar, has retrieved the Apple. What will Callum do?