Wounded by a bullet that grazed his head and suffering from severe memory lapses, Professor Langdon is hospitalized in Florence. Unable to explain his predicament to his attending doctor in the emergency department, Dr. Sienna Brooks, the Professor is in constant pain, bombarded by hellish visions of sinners damned eternally and riddled with questions about the events that preceded his accident. The safety of his room is though fragile and short-lasting, as unknown forces, violently attempt to locate him in order to retrieve a hi-end, fingerprint-protected container that links Langdon to Bertrand Zobrist, a billionaire biomedical engineer, with a vision of a better world stemming from Dante Alighieri's Inferno. Once again on the run, with the help of Dr. Sienna, they will try to navigate through the obscure conspiracy that lies before them, attempting to decipher even the slightest of clues, in a wild hunt all over Europe. "Cerca Trova" or "Seek and ye shall Find", however, in the end of the line when the search is finally over, what mysteries are going to be unveiled?