Pulled away from his vacation, IMF agent Ethan Hunt is given his latest assignment, where Ethan is assigned to recruit Nyah Nordoff-Hall, a beautiful thief and require her skills. After recruiting Nyah, Ethan's boss, Mission Commander Swanbeck gives Ethan the assignment. Renegade IMF agent Sean Ambrose, has killed a old friend of Ethan's, Russian scientist Dr. Nekhorvich, and has stolen "Chimera" a engineered virus and "Bellerophon" the cure, Dr. Nekhorvich create and was carrying to Atlanta, whilst accompanied by Sean who was disguised as Ethan. Ethan learns Nyah was Sean's former lover and has been really recruited to help Ethan track down Sean. After tracking down Sean, Ethan, Nyah, old friend and fellow IMF agent, computer expert Luthor Stickell and Australian helicopter pilot Billy Biard arrive in Sydney, Australia. Where Ethan's mission is to destroy the "Chimera" virus and recover the "Bellerophon" cure and stop Sean and a group of international terrorists from unleashing the "Chimera" virus and infecting the whole world and save Nyah who has been infected and find the cure, before she dies of a terrible death.